Drug Development for Neurological Disorder


Neurological Disorder, such as Alzheimer’s disease, Parkinson’s disease, and the polyglutamine diseases, have been defined as a group of intractable disorders, which are characterized by the progressive degeneration of neurons in various regions of the brain, resulting in neurological and psychiatric symptoms. Molecular genetics and biological studies have revealed that most neurological disorder are caused by protein misfolding and aggregation, and hence they are considered to belong to the so-called protein misfolding diseases. They are propagated by prion-like infectious mechanisms. Therefore, various therapeutic strategies targeting protein misfolding and aggregation are being extensively explored. The development of anti-misfolding and anti-aggregation agents that are commonly effective against a wide range of neurological disorder is eagerly anticipated in the near future.


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