Clinical Immunology, Neuropharmacology and Drug Development

Immunopathology of COVID 19

Even though Corona virus has responsive stimuli for ACE2-expressing animal tissue cells of the tract, general hyper inflammation are that the severe symptom in patients with COVID-19. General inflammation causes dilation, and permits inflammatory white blood cell and monocytic infiltration of the respiratory organ and therefore the heart. Especially, pathogenic GM-CSF-secreting T-cells were shown to correspond with the employment of inflammatory IL-6-secreting monocytes and severe respiratory organ pathology in COVID-19 patients. Infiltrates of lymphocytes have conjointly been according at autopsy. Organs are principally plagued by associate degree inflammatory response in patients with fatal COVID-19.

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  Systemic hyper inflammation


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  Vasodilation


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  Pneumonia